Comparison of zwitterionic N-alkylaminomethanesulfonic acids to related compounds in the Good buffer series

• Robert D. Long,
• Newton P. Hilliard Jr,
• Suneel A. Chhatre,
• Tatiana V. Timofeeva,
• Andrey A. Yakovenko,
• Daniel K. Dei and
• Enoch A. Mensah

Beilstein J. Org. Chem. 2010, 6, No. 31, doi:10.3762/bjoc.6.31

• unstable at elevated temperature (as when autoclaving) – thus limiting their utility. Keywords: aminomethanesulfonate buffers; Good buffer; morpholinomethanesulfonic acid; pKa comparison; zwitterion; Introduction Some of the most widely used biological buffers are the compounds based on tertiary and

• synthesis of Good buffers. Synthetic routes investigated. pKa comparison of aminoalkylsulfonates. Acronyms refer to compounds in the Good’s buffer series that are commercially available. Some of the less common ones are CHES [2-(cyclohexylamino)ethanesulfonic acid], EPPS [4-(2-hydroxyethyl)-1